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Review on Kadamba plant

Review on Kadamba :

Description of the plant:
Biological Source: Drug consists of dried stem bark of Anthocephalus chinensis(Lamk.) A. Rich. ex Walp. (Plate ) (Syn. A. cadamba (Roxb.) Miq.; A. indicus A. 
Family: Rubiaceae
Distribution: It is a large deciduous tree, found all over India in moist, warm, deciduous and evergreen forests.
Other Names
Assam. - Roghu, Kadam
Beng. - Kadam
Guj. - Kadamb, Kadam
Hind. - Kadam, Kadamb
Kan. - Kadamba, Kadamba mara, Kadavala

A large tree, branches spreading, bark dark-brown. Leaves simple, opposite, entire,caducous,coriaceous, stipules lanceolate. Inflorescence  globose, penduncled solitary head; flowers orange colored with white stigma, scented at night. Fruit confluent into a fleshy globose mass. yellow or orange-colored, scented flowers; fruit a fleshy, orange, globose pseudocorp of compressed angular capsules with persistent calyx; seeds small, muriculate.
Anthocephalus cadamba family Rubiaceae amedium sized tree the attaining 2m. girth and 18m. high. Branches spreading horizontally and slightly enlarged at their junction with the main stem. Bark dark brown, roughish, with shallow fissures, 
exfoliating in small irregular woody scales. Blaze 2.2-.3.3 cm. very fibrous, pale yellow, rapidly turning dirty greenish brown on exposure. Leaves 15-30 by 10-17 cm, elliptic-oblong or ovate, acute or shortly acuminate, base usually rounded or subcordate and abruptly cuneate on the petiole, glabrous and dark glossy green above with paler midrib and lateral nerves, glabrous or pubescent beneath. Coriaceous, secondary nerves 10-14 pairs, prominent beneath, curving upwards towards the leaf -margin, base decurrent on the midrib. Stipules 1.3-1.6 cm. long. Petiole 2.5-6.3 cm.long terete. Flowers small, orange or yellow in globose heads, which are solitary and terminal and 2.5-4.5cm. Diameter. Corolla 1.3cm. long. Stigmas white, much 
exserted.Fruit a globose pseudocarp 5-6.3cm. diam., yellow when ripe.

Traditional Uses:

Kadamba is one such Ayurvedic remedy that has been mentioned in many Ayurvedi literatures for the treatment of fever, anemia, uterine complaints, menorrhigia, blood and skin diseases, diarrhoea, colitis, stomatitis, dysentery and in improvement of 
semen quality. Anthocephalus indicus grows throughout India, especially at low levels in wet places. In traditional system of remedies warm aqueous extract of Anthocephalus indicus leaves have been used to alleviate the pain, swelling and for cleansing and better wound healing. Recently, Anthocephalus indicus has been reported to possess antimicrobial, wound healing, antioxidant, ant malarial and hepatoprotective activity. The fruit juice of the plant augments the quantity of breast milk of lactating mothers and also works as a lactodepurant. Root extract of this plant is salutary in urinary ailments like dysurea, calculi and glycosuria . The bark is pungent, bitter, sweet, acrid, saline, aphrodisiac, cooling,indigestible, galactagogue, astringent to the bowels, vulnerary,alexiteric, good in uterine complaints,blood disease, strangury, “Vata”, “Kapha”, biliousness, burning sensation. The fruit is 
heating, aphrodisiac, causes biliousness when ripe. The sprouts are acrid, aphrodisiac, stomachic, cure leprosy and dysentery. The bark is used as a febrifuge and tonic. In the konkan, the fresh juice of the bark is applied to the heads of infants when the 
fontanelle sinks, and a small quantity mixed with cumin and sugar is given internally.
In inflammation of the eyes, the bark juice, with equal quantities of lime juice, opium and alum is applied round the orbit. A decoction of the leaves is used as a gargles in cases of stomatitis. In some parts of Tong King the bark is given for coughs, in some other parts for fever. The bark is generally considered tonic. Charaka prescribes the bark in the treatment of snake bite; but the bark is not an antidote to snake- venom. 

Chemical Investigation :

There are reports that heartwood, leaves, flower and seeds of A. indicus contain typical alkaloid; Cadambine and its derivatives, some complex polysaccharides and other common constituents . A. indicus have shown that heartwood and leaves of 
this plant contain cadambine, 3a and 3b isomers of dihydrocadambine and isodihydrocadambine . It has been reported that its stem bark contains 
cadambagic acid along with quinovic acid and b-sitosterol . Moreover, a complex polysaccharide from flowers and seeds of A. indicus has been isolated.Chlorogenic acid isolated from A. indicus (Cadamba) has been reported to be a potent hepatoprotective agent . Glycosidic alkaloid, triterpenic acid, and saponins is also present in stem bark of kadamba.

Pharmacological application of plant:

 Kumar V., et al (2008) studied the lipid lowering activity of Anthocephalus indicus root extract in triton WR-1339 induced hyperlipidemia in rats. In this model,feeding with root extract (500mg/kg b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50–500 mM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The results of the present study demonstrated both lipid lowering and antioxidant 
activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.
 Kapil (1995) reported antihepatotoxic effect of chlorogenic acid CGA fromAnthocephalus cadamba by in vitro and invivo assays methods using
carbontetrachloride (CCl4) as a model of liver injury. Intraperitoneal administration of CGA to mice at a dose of 100 mg/kg body weight for 8 days
caused significant reversal in lipid peroxidation, enzymation leakage, cytochrome P450 (CytP450) inactivation and produced enhancement of
cellular antioxidant defence in CCl4-intoxicated mice, revealing that the antioxidative action of CGA is responsible for its liver protective activity. 
CGA exhibited a better therapeutic protective action than silymarin (SM) in CCl4 administered mice.D.
 Umachighi S.P., et al (2007) had reported antibacterial, wound healing and antioxidant activity of bark of Anthocephalus cadamba by the disc diffusion method. The plant showed significant antibacterial and antifungal activity against almost all the organisms and especially good activity was found against the dermatophytes. A. cadamba extract has potent wound healing capacity as shown from the wound contraction and increased tensile strength. The results also indicated that A. cadamba extract possesses potent antioxidant activity by inhibiting lipid peroxidation and increase in the superoxide dismutase (SOD) and catalase activity. 

 Acharyya1 S et al. studied on glucose lowering efficacy of the Anthocephalus cadamba roots. The methanol and aqueous extracts of the roots of 
Anthocephalus cadamba was tested for hypoglycaemic activity in normoglycaemic and alloxan induced hyperglycaemic rats at dose levels of 100, 200 and 400 mg/kg, p.o. respectively. Theextract was further subjected to oral glucose tolerance test in normal rats. The hypoglycaemic activity of the root was compared with the reference standard glibenclamide (2.5 mg/kg, p.o.). The study revealed that the roots extract caused significant reduction in the blood glucose level in both normoglycaemic and alloxan induced diabetic 
rats at the tested dose levels in a dose dependant manner. In glucose-loaded animals, the extract also reduced the elevated blood glucose concentration.
 Ambujakshi H.R. et al. Analgesic activity of Anthocephalus cadamba leaf extract Journal of Pharmacy Research 2009, 2(8), 1279-12801279-1280 
investigated the analgesic activity of Anathocephalus cadamba leaf extract using acetic acid induced writhing test and a hot plate method. Aqueous extract of Anathocephalus cadamba leaves showed significant reduction in the number of writhing induced by acetic acid and increased reaction time in hot plate test.
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Pathophysiology of Hyperlipidemia

Pathophysiology of Hyperlipidemia 

An understanding of the biology of the lipoproteins and the pathophysiology of hyperlipidemic states is essential to the rational choice of treatment regimen.
• Exogenous pathway:
Route of uptake of dietary lipids: Chylomicrons (CM) are complexes of triglycerides (TG), cholesteryl esters (CE), and apoproteins. After the removal of triglycerides they become chylomicron remnants .
Chylomicrons are degraded by lipoprotein lipase on endothelial cells of adipose tissue and muscle. After removal of TG for storage, the CM remnants are transported to the liver. This results in dietary TG stored in adipose tissue and muscles.

• Endogenous pathway:
Route for distribution of cholesteryl esters (CE) from liver to target cells :VLDL is secreted by the liver into plasma and transported to adipose
tissue and muscles, where lipoprotein lipase extracts most triglycerides. The remnant IDL is either taken up by the liver or circulated until the remaining triglycerides are removed forming LDL particles, rich in cholesterol. LDL is cleared from plasma through LDL receptor-mediated endocytosis. This results in transfer of TG from liver to target cells via VLDL, as well as, transfer of CE from liver to target cells via LDL.
Reverse cholesterol transport is a pathway where cholesterol is transported from atherosclerotic plaques or other lipids back to liver to be
excreted into the faecus via bile. As cell dies and the cell membranes turnover, free cholesterol is released into the plasma. It is immediately absorbed into HDL particles, esterified with a long chain fatty acid by lecithin cholesterol acyl transferase (LCAT), and transferred to VLDL or IDL by a cholesteryl
ester transfer protein in plasma. Eventually, it is taken up by the liver as IDL or LDL, thus resulting in the recovery of cholesterol from cell membranes and reincorporation into LDL pool or return to liver. 

  • Route for cholesterol recovery

Reverse cholesterol transport is a pathway where cholesterol is transported from atherosclerotic plaques or other lipids back to liver to be excreted into the faecus via bile. As cell dies and the cell membranes turnover, free cholesterol is released into the plasma. It is immediately absorbed into HDL particles, esterified with a long chain fatty acid by lecithin cholesterol acyl transferase (LCAT), and transferred to VLDL or IDL by a cholesteryl ester transfer protein in plasma. Eventually, it is taken up by the liver as IDL or LDL, thus resulting in the recovery of cholesterol from cell membranes and reincorporation into LDL pool or return to liver.Liver synthesizes 2/3rd of the total cholesterol made in the body. The rate limiting enzyme is 3-hydroxy-3-methylglutaryl(HMG)-CoA reductase and provides feedback regulation by controlling the cholesterol concentrations in cells.

  • De novo cholesterol biosynthesis

Bile salts are synthesized from cholesterol in the liver, released into the intestine, and recycled. A small amount of bile acid is excreted. This results in 
conversion of liver cholesterol to bile salts for excretion.

  • Cholesterol excretion by enterohepatic circulation

Bile salts are synthesized from cholesterol in the liver, released into the intestine, and recycled. A small amount of bile acid is excreted. This results in 
conversion of liver cholesterol to bile salts for excretion.

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Key Enzyme of Lipid Formation

 Lipid is formed by 

Two convergent pathways for triacylglycerol biosynthesis. The stepwise acylation of glycerol through the two pathways for triacylglycerol synthesis are shown. Abbreviations: fatty acid (FA), glycerol-3-phosphate (G-3-P), G-3-P acyltransferase (GPAT), lysophosphatidic acid (LPA), acylglycerol-3-phosphate acyltransferase (AGPAT), phosphatidic acid (PA), monoacylglycerol (MAG), MAG acyltransferase (MGAT), diacylglycerol (DAG), DAG acyltransferase (DGAT), and triacylglycerol (TAG).

Acyl-CoA: monoacylglycerol acyltransferase (MGAT) 
Acyl-CoA: monoacylglycerol acyltransferase (MGAT) catalyzes the synthesis of diacylglycerols from monoacylglycerols and long chain fatty acyl-CoAs, a first step in the monoacylglycerol pathway that is major route of triacylglycerol synthesis. This  pathway contributes more than 80% of glycerolipid synthesis in the intestinal mucosa.

MGAT isoforms and expression MGAT 1 Mouse MGAT-1, identified by its sequence homology to acyl-CoA:diacylglycerol acyltransferase-2 (DGAt-2),is a predicted 335 aa protein with at least one 
transmembrane domain near the amino terminus . MGAT-1 overexpressed in Sf9  insect cells acylates all stereoisomers of monoacylglycerol equally and uses a variety of acyl-CoAs. Highest activity is measured using 20:4-, CoA, followed by 18:1- and 
18:2- CoAs. Expression with ERCOS-7 cells shows an immunocytochemistry pattern consistent with ER staining. In mouse tissues m-RNA expression is observed in stomach, kidney, uterus, liver, and white and brown adipose tissues.

MGAT-2 was cloned based on sequence homology to the mouse MGAT-1 and MGAT-2.
MGAT-2 is 52% identical to MGAT-1, and is predicted to have 334 aa and to contain at least one transmembrane domain near the N-terminus .Highest mRNA 
expression occurs in the human liver , small intestine , stomach ,kidney, colon and white adipose tissue. Mouse MGAT-2 has been variably reported to be expressed only in small intestine or primarily in small intestine but also in kidney, adipose, stomach, liver, skeletal muscle and spleen.
Expression of MGAT-2 in COS-7 cells showed immunocytochemistry staining consistent with ER and possibly Golgi, although specific subcellular markets were not used. Overexpression of human 
MGAT-2 in SF9 insect cells and in mammalian cells results in marked increases in MGAT activity, as well as a low DGAT activity.

Human MGAT 3 was cloned based on similarity to DGAT-2 and has 49% identity to DGAT-2, 44% identity to MGAT-1, and 46% identity to MGAT-2. Overexpression of MGAT 3 in Sf9 insect cells shows that MGAT 3 encodes for a 36 kDa protein which 
is predicted to have as many as five transmembrane domains. Human MGAT 3 is 
highly expressed in the gastrointestinal tract, particularly in ileum, but with 3- to 4-fold lower expression in duodenum, jejunum, saecum, colon, rectum, and liver. 
The high expression in ileum is surprising because dietary lipid is almost completely absorbed in the duodenum and jejunum unless fat intake is very high.MGAT-3 expressed in Sf9 insect cells prefers sn-2-monoacylglycerol and uses a broad range of 
acyl-CoAs, but highest activity is observed with 16:0- and 18:1-CoA.

Role of MGAT
MGAT role  in biosynthesis of triacylglycerol 
Dietary fat triacylglycerol is digested by pancreatic lipase to 2-monoacylglycerol and free fatty acids prior to its absorption in the intestinal lumen. The adsorbed 2-monoacylglycerols and free fatty acids are resynthesized to triacylglycerol by enterocytes.Monoacylglycerol pathway and glycerol 3 phosphate pathway are two pathway for synthesizing diacylglycerol. from that tracylglycerol is synthesized with the help of DGAT. In the monoglyceryl pathway, MGAT produces diacylglycerol, the precursor of triacylglycerol and certain phospholipids, by covalently joining a fatty 
acyl moiety to monoacylglycerol. In the glycerol phosphate pathway, diacylglycerol is derived from the dephosphorylation of phosphatic acid (PA), which is produced by sequential acyaltion of glycerol 3-phosphate.

Role of MGAT inhibitors Oleate and sphingosine are MGAT inhibitors. 
Inhibition of MGAT leads to inhibition of triacylglycerol biosynthesis. Inhibition of MGAT lead to inhibition of signaling pathway since its enzymatic product diacylglycerol is an activator of protein kinase C as well as an intermediate in the 
synthesis of phospholipids

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Vacany in Goverment jobs for various position

Job as Pharmacists (5 posts) in NHM - Govt Job.


National Rural Health Mission logo


Applications are invited for various post like pharmacist, Assistant medical officer, staff nurse, Lab Technician, Psychologist,Optometrist, DentalTechnician  of National Health mission, District Bastar, Chattisgarh.

Detail about Pharmacist post: 

Post: Pharmacist (RBSK).
No.of post: 05.
ST: 04, OBC:01.
Eucational Qualification:
Degree  or  Diploma  in  Pharmacy (50%)  &  Registration  in Pharmacy  Registration  council.
Consolidate Salary: 10,000/- Per Month.
Age: 18 - 64 years (as on 1 January, 2016)

Detail about Asst. Medical Officer Post:
Post: AMO (RBSK).
No.of post: RBSK.
(Male) 06 (Female) 04
ST: 04, OBC:01
Eucational Qualification:
BHMS/BAMS/BUMS Degree Registration From any GOI Recognized (BAMS/BHMSA4UMS) Ayush Homeo, Unani Registration Board.
OR BDS with registration in Chhattisgarh Medical Council.
Consolidate Salary: 20,000/- Per Month.

Detail about Staff Nurse Post:

Post: Staff nurse (NUHM).
No.of post: RBSK 1.
Eucational Qualification:
BSC Nursing OR GNM Course Passed & Live Registration in Chhattisgarh Nursing Registration Council.
Consolidate Salary: 12,500 /- Per Month

Detail about Lab Technician Post:

Post: Lab Technician.
No.of post: RBSK 1.
Eucational Qualification:
D.M.L.T. OR B.M.L.T. Course with Registation in C.G. Paramedical Council.
Consolidate Salary: 10,000 /- Per Month

Detail about Dental Technician Post:
Post: Dental Technician.
No.of post: RBSK 1.
Eucational Qualification:
Diploma in Dental Technology from a recognized institution. Preference will be given to candidates having at Ieast 2 years Post Qualifi cation experience
in related field.
Consolidate Salary: 15,000 /- Per Month

Detail about Optometrist Post:
Post: Dental Technician
No.of post: RBSK 1
Eucational Qualification:
Diploma in Optometry from a recognized lnstitute However. Caldidates
having Masters/Bachelor Degree in Optometry will be given preference
Consolidate Salary: 15,000 /- Per Mont

Documents may needed -
10th marksheet
12th marksheet
all marksheets of Degree or diploma
Certificate of registration in pharmacy council
Caste certificate
Domicile certificate
Experience Certificate
Employment Registration certificate
Other related certificates

Last Date for Submission of Application is: 30/03/2016

As Per the advertisement published on date 01/03/2016 the application should reached before 30/03/2016 evening 5.00 pm by speed post/ reg ad. Late application will not be considered.

About Baster

Bastar is a District of the State of Chhattishgarh in Central India. Jagdalpur is the District and Divisional Headquarter. Bastar District  has an area of 4029.98 km². The District is surrounded by Kondagaon,Sukma,Dantewada ,Bijapur Districts of Chhattishgarh. District Bastar has population of 1,411,644 [including Kondagaon Dist.]of which male and female were 697,359 and 714,285 respectively in census 2011. Of the total population more than 70 per cent are tribal people like Gond Tribe, Maria,  Muria ,Dhruva, Bhatra, Halba Tribe, etc. Bastar District is divided into Seven Blocks namely  Jagdalpur ,Bastar, Bastanar , Bakawand, Darbha,    Tokapal ,Lohandiguda and Seven Tahsils Namely  Jagdalpur ,Bastar, Bastanar , Bakawand, Darbha,    Tokapal ,Lohandiguda.The Land of Tribals and Natural Resources, is also enriched with natural beauty and pleasant atmosphere. It is surrounded with dense forests, hilly mountains, streams, waterfalls, natural caves, natural parks etc. Here the art & culture are the valuable ancient properties of the Bastariyas.  

Get all notification and application click here.

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Opportunity for the Post of Manager for B.Pharm & M.Pharm at Government job

Great opportunity for B.Pharm&M.Pharmacy, i need Government jobs At GMSCL,Gandhinagar.
For the post of Manager in various areas of field, Experience candidates required and candidates should be registeredv in Gujarat pharmacy council.
More details about experience and qualifications of candidates are given below :
Gujarat Medical Services Corporation Limited Gandhinagar  invites application for following posts on contractual basis for a Period of 11 months. Applications along with attested copies of educational certificates, certificate in proof of age, experience certificates. Application sent through speed post only by 11/04/2016 at 18:30pm
Post: Manager
No. of Posts:
Manager (Drug, Procurement) - 01
Manager (Equipment, Procurement) - 01
Manager (Equipment, Maintenance) - 01
Manager (Legal) - 01
Manager (Audit) - 01
Manager (M.I.S) - 01
Remuneration: Rs.30,000/- Per month (Fixed Pay)
M.Pharm degree with 3 years of experience in pharmaceutical. Registration in Gujarat Pharmacy Council.
or B.Pharm degree (first class) with MBA (full time) with supply chain management subjects and 3 years of related experience.
For all the above mentioned posts educational qualification, age, experience, for more information visit Gujarat Medical Corporation Services Limited's website, 
Download application form from the website:
The Envelop must be super scribed with the name of the post applied for. Incomplete application will not be considered.
Eligible candidate should sent their Application with educational certificates, certificate in proof of age, experience certificates, complete in all respect should be received by speed post in a sealed cover addressed to “Managing Director, GMSCL Block No 14, 1st Floor, Dr.Jivraj Mehta Bhavan, Gandhinagar” latest by 11/04/2016.
Applications received in the office after the due date and time shall be summarily rejected

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Opportunity for Freshers in Indian Government as Pharmacist, Nurse, Technician & Specialist (pediatric, radiology, ENT)

Opportunity  for freshers in Indian government.

For various post like Jr. Pharmacist, staff nurse, lab technician, doctors ,dietitian more.... ...

SAIL, a Maharatna Company, and a leading steel-making company in India with a turnover of 49350 crores (FY 2012-13) is in the process of modernizing and expanding its production units, raw material resources and other facilities to maintain its dominant position in the Indian steel market. Bokaro Steel Plant, one of the modernised integrated steel plants of SAIL employing a motivated workforce of around 18000 employees is producer of HR Coils/Sheets/Plates, CR Coils/ Sheets, GP Sheets/Coils. Bokaro Steel is working towards becoming a one-stop-shop for world-class flat steel in India.
SAIL, Bokaro Steel Plant invites online applications from energetic, dynamic medical professionals as Consultant/Specialists for its Bokaro General Hospital , which is a prestigious 910 bed hospital with state of the art equipment, recognised by NBE for DNB teaching in many specialities. Opportunities are also being offered for paramedical staff in the following disciplines for providing best healthcare facilities at Bokaro General Hospital and its Health Centres.
For the post of Specialist(s), there is a Special Recruitment Drive in SC & OBC category. 
1 Specialist (Paediatrics/Radiology/ENT) 
2 Principal School of Nursing 01.
3 Jr. Staff Nurse Trainee 15 
4 Jr. Technician Trainee (Medical Lab) 02
5 Jr. Pharmacist Trainee 08
6 Jr. Technician Trainee (Radiography) 02
7 Jr. Dietician Trainee 01
8 Jr. Technician Trainee (OT) 05
 posts are reserved for SC/ ST / OBC (Non Creamy Layer) / Persons with Disabilities
Upper Age Limit (As on 04/04/2016): 
For Posts at Sl 1 (ME3) : 37 Yrs
For Posts at Sl 2 (ME1) : 34 Yrs
For Posts at SL 3 to 8 : 28 yrs. 
Relaxable by 5 years for candidates belonging to SC/ST category, 3 years for candidates belonging to OBC 
(Non-creamy layer) respectively with respect to posts reserved for them. The non-creamy layer status 
should be valid on the closing date of receipt of application (i.e. 04/04/2016). Additional relaxation of 10 
years in age to Persons with Disabilities. Ex-Service men (ESM), who have put in not less than 6 months 
continuous service in the armed forces, will be allowed age relaxation to the extent of military service 
plus three years against reserve/unreserved vacancies as per government guidelines.
Departmental candidates (employees of SAIL) will be given relaxation of 10 years over and above the 
upper age limit. However, for Induction level examinations, the upper age limit for the departmental 
candidates will be 45 years for S3/E1 level posts, irrespective of the category of the candidate. 
Those domiciled in the state of Jammu & Kashmir from 1/1/80 to 31/12/89 will be allowed 5 years 
relaxation in upper age limit.
Post: Jr.pharmacist 
No.of post: 08
UR-04, ST(C) - 02, ST(BL) - 01, OBC(NCL) - 01
Pay Scale & Grade: # Regular Grade on successful  completion of two years of training. Pay Scale (S3 Regular Grade) - Rs.  16800/- 3%- 24110/-
Upper Age Limit (As on 04/04/2016): 28 yrs.
Essential Qualification and Experience (As on 04/04/2016):
Full time Degree in Pharmacy (with 50% marks for GEN/OBC & 40% marks for SC/ST/PWD/Departmental candidates) or 10+2 (Science) with Full time Diploma in Pharmacy (with 50% marks for GEN/OBC & 40% marks for SC/ST/PWD/Departmental candidates) of minimum 2 years duration and registered with Pharmacy council of India/State Pharmacy council and with at least 1yr post qualification experience in a Hospital/Nursing Home.
Eligible candidates for post of Jr. Pharmacist Trainee will be required to appear in Written Examination. The minimum qualifying marks in Written Test will be determined based on 50 percentile score (for UR Category) and 40 percentile score (for SC/ST/OBC(NCL)/PWD) candidates. Candidates who qualify in the written test will be called for Trade Test / Skill Test in the ratio of 1:3. Trade Test / Skill Test will be only qualifying in nature and the final merit list of candidates who qu alify the Trade Test / Skill Test will be prepared on the basis of marks obtained in the written test only. Information for Written test and Trade Test/Skill Test will be provided on our website only.
Candidates  selected  for post of Jr. Pharmacist Trainee will  be  placed  on  training  for a  period  of  2  Years which  may  be  extended  by  another  two  years  as  per  requirement.  On  successful  completion  of  training  period,  they  shall  be  regularized in  S-3 Grade.  After  successful  completion  of  Training,  Candidates  shall  be  placed  under probation for 1 year.
Candidates selected for S-3 grade for posts at Jr. Pharmacist Trainee will be paid consolidated Pay of Rs. 10700/- pm during 1st year of training and Rs. 12200/- pm during the 2nd year of training. During the period of 2 year training, Trainees will also get Medical facility for self, spouse and dependent children. Leave etc will be as per the Rules of the Company.
The emoluments for the post at Jr. Pharmacist Trainee on confirmation after 2 years of training will include basic pay, industrial dearness allowance, reimbursement of local travelling expenses and other facilities such as medical facili ty for self and family, provident fund, gratuity, LTC, etc., as per rules of the company. In addition, House Rent Allowance will be paid only where company accommodation is not available. Pay Scale of S3 grade is Rs. 16800/ - 3% - 24110/-.

Eligible and interested candidates would be required to apply online through SAIL’s website: (Career with sail). No other means /mode of application will be accepted 
Before applying the candidates should ensure that they fulfill all the eligibili ty norms. Their registration will be provisional as their eligibility will be verified only at the time of interview /Trade Test /Skill Test . Mere issue of admit card /interview/Trade Test/Skill Test call letter will not imply acceptance of candidature. Candidature of a registered candidate is liable to be rejected at any stage of recruitment process or even on joining, if any information provided by the candidate is found to be false or not in conformity with the eligibility criteria at any stage or if candidate fails to produce valid documentary proof in support of his eligibility.
Before registering their applications on the website the candidates should possess the following:a) Valid e - mail ID, which should remain valid for at least one year.
b) Candid ates should ensure that they possess requisite qualification at the time of applying.
c) Provision to pay application fee for the post at sl 1 of 500/- (Non- refundable) for OBC Candidates , application fee for the post at sl 2 of 500/- (Non-refundable) for General & OBC Candidates and application fee for the posts at sl 3 to 8 of 250 /- (Non - refundable) for General & OBC Candidates. Candidates can opt to pay through internet banking account or credit card/debit card/cash at SBI branch, through SB collect. SC/ST /PwD/ESM/Departmental candidates are exempted from payment of Application fees.
d) Candidates should have latest colour passport size photograph as well as photograph of signature in digital form (.jpg or .jpeg only of less than 500 kb size) for uplo ading with the application form.
e) Candidates are advised to read carefully instructions for online submission of application. The same will be available in the website itself.
f) While filling on - line application the candidates must carefully follow all the steps. Incomplete application/application without fee/application not fulfilling any eligibility criteria will be rejected summarily. No communication will be entertained from applicants in this regard.
g) After applying online, candidate is required to downloa d the system generated Provisional Registration Slip with unique registration number and other essential details.
h) Candidates are not required to send any document to Bokaro Steel Plant at this stage. The candidates will be allowed to appear in the Written Test only if they possess the valid Photo Admit Card which will be available for downloading from the SAIL website as per schedule indicated below.
i) The application being online, if during verification of documents prior to interview/Trade Test/Skill Test, it is found that the candidate does not possess the requisite eligibility criteria, he/she will not be allowed to appear for the interview / Trade Test / Skill Test.
Closing date for submitting applications through website: 04/04/2016.
Advt. No. BSL/R/2016 - 01.

Get all details about other post salary details all get through link.

For more information click here .

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Opening in Novartis

Opportunity for Pharm.D. and B.Pharm 

There is  Recruitment in Novartis 

Opening in Novartis

For the Post of Pharmacovigilance.
A global healthcare leader Today   Novartis has one of the most exciting product pipelines in the industry. A pipeline of innovative medicines brought to life by diverse, talented & performance driven people. All of which makes them one of the most rewarding employers in their field.
Post : Pharmacovigilance Expert
Job work Details 
Provide support to the Brand Safety Leader/Pharmacovigilance Leader (PVL/BSL) in monitoring the safety profile of assigned products by providing quality deliverables within agreed timeframes and adhering to a high standard of accuracy in compliance with IMS business rules, standard operating procedures and global and local regulatory requirements.
1. Assist the BSL/PVL in monitoring the safety profile of products potentially including activities such as literature review, evaluation of individual cases or signal detection. Medical review of single case reports will be performed by associates possessing medical degree.
2. Together with the BSL/PVL, co-author the PSUR including analytical input to PSUR for known and potential risks defined in the RMP.
3. With BSL/PVL, assist in the development, maintenance and implementation of the RMP including the coordination with other line functions for associated activities such as updates, management of large datasets for analysis purposes and the ongoing tracking of commitments and effectiveness measures
4. Assist in evaluating and writing other safety deliverables including but not limited to clinical overviews, ad hoc health authority queries, drug safety product profile (DSPP), drug safety update report (DSUR)
5. Assist in providing safety input to DRA and clinical documents (e.g. core data sheet and investigator brochure)
6. Play an active role in standing and ad hoc Safety Management Team (SMT) and Safety Project Team (SPT) meetings
7. Play an active role in SIGDET and MSRB meetings including preparatory activities
8. Interface with the clinical team for safety matters including follow-up on events of interest and input into site queries regarding adverse events, updating on PVO requirements
1. Quality of work delivered (attention to details, thoroughness, medical sound judgment, writing)
2. Timeliness of deliverables according to established directives
3. Compliance with Internal and external regulations and procedures
4. High level of independence
Candidate Profile
Bachelor of Science in Pharmacy /Bachelor of Science in Nursing / PharmD/PhD in relevant field or Medical Degree (MBBS or MD) required. Medical degree is essential for associates performing medical requirements

Good knowledge/fluency in English.
Knowledge of other languages desirable.
Education (minimum/desirable):
Bachelor of Science in Pharmacy /Bachelor of Science in Nursing / PharmD/PhD in relevant field or MD
Languages: Good knowledge/fluency in English. Knowledge of other languages desirable.
Experience/Professional requirement:
• May be a first job in the pharmaceutical industry for an MD with 3 or more years of clinical experience after graduating from medical school
• Experience in safety document or medical writing including experience coding with MedDRA and WHO dictionaries in preparation of these reports preferred
Additional Information:
Job ID: 184915BR
Experience: 3-5 Year
Industry Type: Pharma/Biotech/Clinical Research
Location: Hyderabad
Functional Area: Pharmacovigilance
End Date: 20th April, 2016
Apply through this link .

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Zika Virus Symptoms, Diagnosis & Treatment

Zika Virus 

Zika virus disease (Zika) is a disease which is caused by Zika virus that is spread to people primarily by the bite of an infected Aedes species mosquito. The most common symptoms of Zika arefever, rash, joint pain, and conjunctivitis (red eyes).

Symptoms, Diagnosis, & Treatment


  • Most of the people infected with Zika virus won’t even know they have the disease because they won’t have symptoms. The most common symptoms of Zika are fever, rash, joint pain, or conjunctivitis (red eyes). Other common symptoms include muscle pain and headache. The incubation period (the time from exposure to symptoms) for Zika virus disease is not known, but is likely to be a few days to a week.
    • See your healthcare provider if you are pregnant and develop a fever, rash, joint pain, or red eyes within 2 weeks after traveling to a place where Zika has been reported. Be sure to tell your health care provider where you traveled.
  • The illness is usually mild with symptoms lasting for several days to a week after being bitten by an infected mosquito.
  • People usually don’t get sick enough to go to the hospital, and they very rarely die of Zika. For this reason, many people might not realize they have been infected.
  • Zika virus usually remains in the blood of an infected person for about a week but it can be found longer in some people.
  • Once a person has been infected, he or she is likely to be protected from future infections.


  • The symptoms of Zika are similar to those of dengueand chikungunya, diseases spread through the same mosquitoes that transmit Zika.
  • See your healthcare provider if you develop the symptoms described above and have visited an area where Zika is found.
  • If you have recently traveled, tell your healthcare provider when and where you traveled.
  • Your healthcare provider may order blood tests to look for Zika or other similar viruses like dengue or chikungunya.

Treatment of zika virus 

  • There is no vaccine to prevent or medicine to treat Zika infections.
  • Treat the symptoms:
    • Get plenty of rest.
    • Drink fluids to prevent dehydration.
    • Take medicine such as acetaminophen (Tylenol®) or paracetamol to relieve fever inflammation  pain.
    • Do not take aspirin and other non-steroidal anti-inflammatory drugs.
    • If you are taking medicine for another medical condition, talk to your healthcare provider before taking additional medication.
  • If you have Zika, prevent mosquito bites for the first week of your illness.
    • During the first week of infection, Zika virus can be found in the blood and passed from an infected person to a mosquito through mosquito bites.
    • An infected mosquito can then spread the virus to other people.
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Opening in MNC Pharmaceutical Freshers & Experience

Walk in interview - MACLEODS

As post Officer,  Senior Officers in different departments 

walk in interview in Macleods Adv.
Macleods, India’s fastest growing pharmaceutical company, with manufacturing sites approved by USFOA & WHO Geneva, ranked among the top pharmaceutical companies with strength of 10,000 employees, operating 60 countries worldwide, required talented professionals for Formulation Plant at Baddi (HP), Sikkim & Sarlgam.
Designation: Officer, Senior Officer

Department -Quality Control 
Fresher/ Officer/Sr.Officers - Quality Control
Qualification: B.Sc/ M.Sc/B.Pharm/M.Pharm
Experience: 0-6 years - Raw Material, Finished Product & Stability, with experience on Analytical Instrumentation - HPLC, GC, and UV IR
Department - Production 
Fresher/Officer/Sr.Officers - Production/Packing

Qualification: B.Pharma/M. Pharma
Experience: 0-8 years (Granulation/compression/coating) Strip/blister, Bulk packing.
Technical Associate- Production /Packing 
Qualification: ITI/ Diploma/B.Sc
Experience: 0-8 years - Granulation /compression /coating/ Strip /blister & Bulk packing machine.
Department -Quality Assurance 

Qualification: B Pharma/M Pharma
Experience: 0-5 years (In process quality Assurance)

Time for walk in interview 9.30 am -6.30 pm with  resume salary proof on 13-03-2016
On Sunday 
Hotel K C Cross, Opp.Bus Stand, Sector-10
Ponta Sahib: Hotel Lamba Celebrations Resort
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